PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA

EVALUASI PENGGUNAAN OBAT ANTIHISTAMIN PADA PASIEN PENYAKIT KULIT DI APOTEK GEJAYAN DEPOK SLEMAN

2023-05-15T03:46:50+00:00

Abstract

Background: Skin disease was included in the top ten diseases at the Yogyakarta regional health center in 2014. Skin disease can be caused by infection or allergies. One of the drugs used to treat skin diseases is antihistamines.

Objective: To evaluate the use of antihistamines in patients with skin diseases at the Gejayan Pharmacy, Depok, Sleman for the November-December 2021 period.

Method: This study used an analytic observational method, with retrospective data collection. Sampling used a purposive technique on prescriptions and medical records of skin disease patients for the November-December 2021 period, a total of 286 samples. Data were analyzed descriptively quantitatively on patient characteristics, use of antihistamines, and evaluation of the use of antihistamines in terms of the right drug and the right dose.

Results: The results of this study showed that there were 84.3% of skin disease patients aged 15-64 years, and 15.7% aged ≥ 65 years. Patients with female sex of 57.7% and male by 42.3%. The highest patient diagnoses were contact dermatitis at 24.5%, atopic dermatitis at 12.9% and urticaria at 10.1%. The most widely used type of antihistamine drug was CTM with 22.7%, followed by ryzicor with 17.1% and river with 9.1%.

Conclusion: Evaluation of drug use based on the right drug is 96.8% and the right dose is 100%.

Mekanisme Kerja Obat Antihipertensi Yang Bekerja Pada GPCRs dan Tanaman Yang Berpotensi Sebagai Antihipertensi

2023-05-15T09:10:29+00:00

Hypertension is the medical term for patients with systolic blood pressure above 140 mmHg and diastolic above 100 mmHg. Hypertension is a complex multifactorial disease that contributes to the main causes of morbidity and mortality in industrialized countries: ischemic heart disease and hypertension, stroke, peripheral atherosclerosis and renal failure. Commonly used antihypertensives are usually associated with many side effects. In the last three decades, many concerted efforts have been made to research local plants with hypotensive and antihypertensive therapeutic value. The hypotensive and antihypertensive effects of some of these medicinal plants have been validated and others have not been proven. G-protein coupled-receptors or GPCRs are targets of drug action, whose signaling is mediated by G-proteins. GPCRs are receptors that reside on the cell surface and have seven transmembrane domains. For example, GPR35 is a target for furosemide and bumetanide. This is especially important in cardiovascular disease secondary to hypertension, where the degree of vessel constriction is partly due to increased levels of agonists such as catecholamines and angiotensin II.

GAMBARAN POLA PERESEPAN OBAT DIARE PADA PASIEN ANAK DI RSUD H. ABDUL MANAP JAMBI PERIODE JANUARI – MARET TAHUN 2022

2023-05-17T03:50:23+00:00

Diarrhea is the second leading cause of death in children under five years old. Globally, there are 1.7 billion cases of diarrhea every year and around 525,000 children die each year.

Objective of this study is to describe the pattern of diarrhea drug prescribing in children based on the type of drug and other therapeutic drug classes.

The type of research used is descriptive quantitative. The population and sample in this study were all prescription sheets of pediatric patients with a diagnosis of diarrhea, namely there were 26 patient prescriptions and the method used in this study was saturated sampling.

The results of the study of 26 pediatric patients showed that the most commonly prescribed diarrhea drugs were zinc and L-Bio (36.5%). Based on other therapeutic drug groups, the highest percentage of drug use is Antiemitics (100.0%).

In Conclusion, Diarrhea drug prescribing based on the type of diarrhea medication that was most often prescribed was Zinc and L-Bio, each amounting to (36.5%). Other Therapeutic Drugs that are widely used or combined with children's diarrhea

Analisis Bahan Kimia Obat Parasetamol pada Jamu Pegal Linu yang dijual di Kecamatan Pasar Jambi, Kota Jambi

2023-08-10T07:58:56+00:00

Background: Chemical drugs that were often added to pegal linu herbal medicine was paracetamol. Paracetamol added as analgesic.

Objective: This study aims to analyze qualitatively the content of Paracetamol in the pegal linu herbal medicine, which is sold in Pasar Jambi District, Jambi City.

Method: This study was conducted qualitatively, samples were taken by purposive sampling, and 8 samples (SA, SB, SC, SD, SE, SF, SG, and SH) were selected from pegal linu medicine that met the inclusive criteria. Samples were tested organoleptically, microscopically, spot test, and TLC.

Results: In the organoleptic test, all herbs were in powder form, SA had a brownish-yellow color with an aromatic odor, SB had a light brown color with an aromatic odor, SC had a greenish-brown color with an aromatic odor, SD had a light brown color with an aromatic odor, SE had a yellowish-brown color with an aromatic odor, SF has a yellowish-brown color with an aromatic odor, SG has a light brown color with an aromatic odor, SH has a greenish-brown color with an aromatic odor. In the spot test, no herbs were found that had the same color reaction as paracetamol. In the TLC test, there were several herbs that had the same Rf value as standard paracetamol. In the 1st, 2nd, and 3rd tests, the Rf value of paracetamol respectively were 0.36; 0.33; and 0.40. Meanwhile, in the sample, it was found that the Rf value was the same as that of paracetamol. In the first test, the samples coded SD and SG, in the second test there were none, in the third test, the herbal medicine samples coded SC and SD.

Conclusion: Pegal linu herbal medicine didn’t contain paracetamol.

DESCRIPTION OF THE LEVEL OF COMMUNITY KNOWLEDGE ABOUT THE USE OF COUGH DRUGS IN THE HAMLET OF KRAGAN, GRABAG, MAGELANG FEBRUARY 2022

2023-08-10T09:20:51+00:00

ABSTRACT

Background: The prevalence of cough is 15% in children and 20% in adults. The knowledge obtained shows that respondents who have a good level of knowledge about cough medicine self- medication are 45% while people with a low level of knowledge are 15%.

Objective: This study aims to describe the level of public knowledge about the use of cough medicine in Kragan Hamlet, Grabag, Magelang.

Method: This research method is descriptive observational with data collection using purposive sampling. The population in this study is the community in Kragan Hamlet, Grabag, Magelang, aged 17-55 years, the data used is primary data collected with a questionnaire instrument. The data were analyzed by calculating the percentage value of correct answers in the questionnaire section, then the level of knowledge was categorized into good, sufficient, poor categories.

Results: The results showed that the level of public knowledge about the use of cough medicine in the good category was 26 respondents (32%), 31 respondents (38%) sufficient and 24 respondents (29%).

Conclusion: The conclusion in this study was that the majority of the community's level of knowledge about the use of cough medicine in Kragan Hamlet, Grabag, Magelang was categorized as sufficient.

PERBANDINGAN KADAR KLOROFIL DAN KAROTENOID DAUN SIRIH MERAH (piper betle) DAN SIRIH HIJAU (Piper ornatum) MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-Vis

2023-10-05T16:19:16+00:00

ABSTRACT

Background: One of the plants that is widely known by the public is betel. Betel is a plant that has been widely used as medicine in Southeast Asia. Betel in Indonesia there are several types, which are distinguished by the shape of the leaves, taste and aroma, namely green betel, banda betel, clove betel, black betel and red betel. Green betel leaf (Piper betle) and red betel leaf (Piper ornatum) contain important components, namely chlorophyll and carotenoids.

Objectives : this study aims to compare the levels of chlorophyll and carotenoids in red betel and green betel.

Metode: Penelitian ini dilakukan dengan menggunakan sirih merah dan daun sirih hijau, 80% aseton dan air suling serta membaca absorbansinya menggunakan Metode Spektrofotometri UV-Vis pada panjang gelombang 663; 645; 480nm.

Hasil: Daun sirih merah memiliki kandungan klorofil sebesar 81,25 mg/L dan daun sirih hijau sebesar 0,350 mg/L. Kandungan karotenoid daun sirih merah sebesar 35,07 mg/L dan daun sirih hijau sebesar 1,956 mg/L.

Kesimpulan: penelitian ini menunjukkan bahwa daun sirih merah (Piper ornatum) memiliki kandungan klorofil yang lebih tinggi yaitu 81,25 mg/L sedangkan kandungan klorofil daun sirih hijau (Piper betle) sebesar 0,350 mg/L. Kandungan karotenoid daun sirih merah (Piper ornatum) lebih tinggi 35,07 mg/L dibandingkan daun sirih hijau (Piper betle) yang sebesar 1,956 mg/L.

Kata kunci: Green betel, red betel, chlorophyll, carotenoids